The department functions in two main Manhattan locations, the main campus at 68th Street and Lexington Avenue and the MFA Studio Building at 205 Hudson Street in Tribeca.

The main campus at 68th Street houses the administration, the Leubsdorf Art Gallery, and the Zabar Art Library with extensive databases including Artstor, a digital source of over one million images in the arts and humanities. It also houses fully equipped workshops on the 11th floor for audio & video production, photography, printmaking, metal, wood and plaster, as well as a computer lab and painting and drawing studios. The basement of Thomas Hunter Hall, the adjacent building, houses the clay workshop.

The MFA Building is a large, unique facility that plays a significant role in the life of the college and, indeed, the city as a whole. The building houses a number of workshops and labs including photography, wood, metal, printmaking and ceramics studios, as well as digital audio and video production labs.